8.6% of which were in Cork.
The figures released in a report by the Health Research Board equate to 11 lives lost each month.
The study shows drug abuse was a significant factor, with 86% of those who died having a history of substance misuse, and nearly half of the deaths caused by drug poisoning.
One in three had known mental health issues, and two-thirds were alone at the time of death.
Most deaths at 80.5% were among men, with a median age of 44, while women had a median age of just 37.
Women were more likely to die in accommodation, while men were more likely to die in public places.
